Program

1st International Stroke-Immunology Meeting
Final program (as planned for April 2020)

WEDNESDAY, APRIL 1st

Session 1: TRANSLATIONAL RELEVANCE

14.30 – 14.55
Ulrich Dirnagl (Berlin, Germany): Studying brain-immune interactions in experimental stroke: Focus on external validity

14.55 – 15.20
Terry Fang (Cambridge, USA): Learnings from longitudinal blood transcriptomics after acute ischemic stroke

15.20 – 15.45
Tim Magnus (Hamburg, Germany): IL-17 as a therapeutic target in ischemic stroke

15.45 – 16.00
Fu-Dong Shi (Beijing, China): Results and ongoing activities on Fingolimod on Stroke

COFFEE BREAK

16.30 – 16.55
Denis Vivien (Caen, France): Do perivascular macrophages protect the brain from inflammation?

16.55 – 17.20
Nikolett Lenart (Budapest, Hungary): The role of microglia in the regulation of cerebral blood flow under normal and inflammatory conditions

17.20 – 17.35
Martin Dichgans (Munich, Germany): Causal role of MCP-1 in human stroke

17.35 – 17.50
Kaibin Shi (Beijing, China): Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke

17.50 – 18.05
Siddharth Krishnan (Manchester, UK): A high-dimensional immunological map of the circulating leukocytes in stroke patients

THURSDAY, APRIL 2nd

Session 2: BRAIN BARRIERS AND BLOOD FLOW

8.30 – 8.55
Jonathan Kipnis (Charlottesville, USA): Meninges as an immune-blood-brain interface in healthy and inflamed brain

8.55 – 9.20
Dorian McGavern (Bethesda, USA): How myeloid cells contribute to BBB damage and recovery following cerebrovascular injury

9.20 – 9.45
Costantino Iadecola (New York, USA): Innate and adaptive immunity effectors of dementia

9.45 – 10.00
Anu Meerwaldt (Utrecht, Netherlands): Imaging hematopoietic response in ischemic stroke

COFFEE BREAK

10.30 – 10.55
Eszter Farkas (Szeged, Hungary): Do microglia modulate spreading depolarization?

10.55 – 11.20
David Brough (Manchester, UK): Understanding the inflammasome and barrier integrity

11.20 – 11.35
Sunghee Cho (New York, USA): Remote post-ischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2+ pro-inflammatory subset

11.35 – 11.50
Mathias Gelderblom (Hamburg, Germany): Role of the T cells in modulating the inflammatory response to cerebral ischemia

11.50 – 12.05
Patrick Strangward (Manchester, UK): Systemic and cellular glucose metabolism cooperatively regulate macrophage activation after ischaemic stroke

LUNCH BREAK

Session 3: ADAPTIVE IMMUNITY & RECOVERY

14.00 – 14.25
Doron Merkler (Geneva, Switzerland): Trapped behind the barrier: Modeling adaptive immune response within the central nervous system

14.25 – 14.50
Magdalena Götz (Munich, Germany): Approaches towards neuronal replacement – from transplantation to direct neuronal reprogramming

14.50 – 15.15
Christoph Kleinschnitz (Essen, Germany): Thrombo-Inflammation in ischemic stroke: from concepts to the clinics

15.15 – 15.40
Corinne Benakis (Munich, Germany): The role of the microbiome-gut-brain axis in stroke

COFFEE BREAK

16.15 – 16.40
Ann Stowe (Lexington, USA): Harnessing B cells to support functional plasticity after stroke

16.40 – 17.05
Andreas Meisel (Berlin, Germany): What B cells do in the ischemic brain

17.05 – 17.20
Stefka Gyoneva (Cambridge, USA) Loss of the a microglial/neuronal signaling axis, TWEAK/Fn14, restores normal synaptic plasticity and augments recovery following acute ischemic stroke without affecting infarct volume

17.20 – 17.35
David Loane (Dublin, Ireland): Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurological deficits

20.00 POSTER SESSION

FRIDAY, April 3rd

Session 4: INNATE IMMUNITY: MICROGLIA & BEYOND I

8.30 – 8.55
Marco Prinz (Freiburg, Germany): Mapping microglial heterogeneity through the integration of high-dimensional techniques

8.55 – 9.20
Stuart Allan (Manchester, UK): Early changes in clinical immunophenotype after ischaemic and haemorrhagic stroke

9.20 – 9.45
Barry McColl (Edinburgh, UK): Endogenous regulation and exogenous manipulation of CNS myeloid cells in brain repair and recovery after stroke

9.45 – 10.00
Lidia Garcia-Bonilla (New York, USA): The inflammatory response to cerebral ischemia at single cell resolution

10.00 – 10.15
Karen Gertz (Berlin, Germany): Role of microglia activity and tryptophan catabolites (TRYCATs) for neurodegenerative disease

COFFEE BREAK

Session 5: INNATE IMMUNITY: MICROGLIA & BEYOND II

10.45 – 11.10
Takashi Shichita (Tokyo, Japan): The role of innate immunity and lipid metabolism in ischemic stroke

11.10 – 11.35
Anna Planas (Barcelona, Spain): Antigen presentation after stroke

11.35 – 12.00
Csaba Cserep (Budapest, Hungary): Somatic purinergic microglia-neuron junctions in health and disease

12.00 – 12.25
Jun Chen (Pittsburgh, USA): The role of ferroptosis, inflammation and hematoma resolution in hemorrhagic stroke

12.25 – 12.40
Ralf Stumm (Jena, Germany): Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte responses to stroke

Meeting will conclude on Friday at approx. 2pm